Please rotate your device to landscape

For the best learning experience, we recommend to use a desktop device.

Early signs of MS

Learning objectives

This module was produced during the 2021 COVID-19 pandemic, where filming has been conducted remotely to adhere to guidelines. For this reason, please forgive a lower production quality than you are used to seeing from us.

This module is intended to help you:

Be aware of the early signs of MS
Understand the relationship between radiologically isolated syndrome and clinically isolated syndrome with clinical MS
Appreciate the importance of detecting cognitive dysfunction in early-stage MS
Be able to provide evidence-based advice on how treatment and lifestyle changes may help to manage early-stage MS

Giovannoni G, et al. Mult Scler Relat Disord. 2016;9(Suppl. 1):S5–48
Burke T, et al. Int J MS Care 2011;13:105–12
Sinay V, et al. Mult Scler. 2014;21:945–52
De Stefano N,et al. Mult Scler. 2018;24:214–21
Sørensen PS, et al. Brain 2020;143:2637–52
Okuda D, et al. Neurology 2009;72:800–5
Thompson A, et al. Lancet Neurol. 2018;17:162–73
McNicholas M, et al. QJM. 2018;111:359–64
Oset M, et al. Curr Neurol Neurosci Rep. 2020;20:22
Reuter F, et al. J Neurol Neurosurg Psychiatry 2011;82:1157–9
Zipoli V, et al. Mult Scler. 2010;16:62–7
Sellner J, et al. J Neurol. 2010;257:1602–11
Sati P, et al. Nat Rev Neurol. 2016;12:714–22
Okuda DT. Mult Scler. 2017;23:1818–19
Kappos L, et al. Neurology 2006;67:1242–9
Comi G, et al. Lancet 2009;374:1503–11
Okuda D, et al. Neurology 2015;84(Suppl. 14):P7.207
Frenay CL, et al. Neurology 2017;88(Suppl. 16):P6.359
ClinicalTrials.gov. Randomized, double-blinded study of treatment: Teriflunomide, in Radiologically Isolated Syndrome (TERIS). Available at: https://clinicaltrials.gov/ct2/show/NCT03122652. Accessed: September 2021
ClinicalTrials.gov. Assessment of Tecfidera® in Radiologically Isolated Syndrome (RIS) (ARISE). Available at: https://clinicaltrials.gov/ct2/show/NCT02739542. Accessed: September 2021
Okuda DT, et al. PLoS One 2014;9:e90509
Zhang H, et al. Neuroimage Clin. 2019;21:101593
Filippi M, et al, Nat Rev Dis Primers . 2018;4:43
Montalban X, et al. MSJ. 2018;24:96–120

Early signs of MS

Clear identification of the early signs of MS and an early diagnosis can facilitate as early intervention as possible in patients with MS to give the best long-term prognosis. This module outlines the current understanding of early signs of MS and discusses how treatment and lifestyle changes may help with its management.

Length
12 min course

Job code
NPS-TPE-NP-00503

Match the left-hand column to its corresponding definition on the right

What proportion of patients with CIS are estimated to be subsequently diagnosed with MS by fulfilling the MRI criteria for dissemination in space and dissemination in time as defined in the 2017 McDonald MS diagnostic criteria?

Select the correct answer

How often should patients with RIS be monitored using MRI?

Click on the correct point in the timeline

It is recommended to monitor patients with RIS every 6 to 12 months by MRI, particularly for individuals who fulfil MRI criteria for DIS because with any new MRI activity they would fulfil MRI criteria for DIT.¹

According to a study by Zipoli et al. 2010, failure of how many neuropsychological tests by patients with CIS predicted conversion to MS?

Select the correct answer

Which of these DMTs are recommended by ECTRIMS/EAN guidelines for patients with CIS and an abnormal MRI with lesions suggestive of MS who do not fulfil criteria for MS?

Select the correct answer(s)

Which of these factors are encouraged for a brain-healthy lifestyle?

Select the correct answer(s)

Early signs of MS

Please note you are now leaving Neurologybytes.com and being redirected to a different website not operated by Teva Pharmaceuticals.

Please rotate your device to landscape

For the best learning experience, we recommend to use a desktop device.

Early signs of MS

Learning objectives

Please click continue to proceed.

Which of these are considered common early symptoms of MS?

Select the correct answer(s)

Please click continue to proceed.

Based on results from a longitudinal study, which statement is correct?

Select the correct answer

Match the left-hand column to its corresponding definition on the right

What proportion of patients with CIS are estimated to be subsequently diagnosed with MS by fulfilling the MRI criteria for dissemination in space and dissemination in time as defined in the 2017 McDonald MS diagnostic criteria?

Select the correct answer

How often should patients with RIS be monitored using MRI?

Click on the correct point in the timeline

It is recommended to monitor patients with RIS every 6 to 12 months by MRI, particularly for individuals who fulfil MRI criteria for DIS because with any new MRI activity they would fulfil MRI criteria for DIT.1

According to a study by Zipoli et al. 2010, failure of how many neuropsychological tests by patients with CIS predicted conversion to MS?

Select the correct answer

Which of these DMTs are recommended by ECTRIMS/EAN guidelines for patients with CIS and an abnormal MRI with lesions suggestive of MS who do not fulfil criteria for MS?

Select the correct answer(s)

Which of these factors are encouraged for a brain-healthy lifestyle?

Select the correct answer(s)

Congratulations!

You have completed module 9

Links and downloadable elements

Early signs of MS

Disability progression

Vaccination and MS

It is recommended to monitor patients with RIS every 6 to 12 months by MRI, particularly for individuals who fulfil MRI criteria for DIS because with any new MRI activity they would fulfil MRI criteria for DIT.¹