Managing migraine with therapies targeting the CGRP pathway – a safety update

The key role of calcitonin gene-related peptide (CGRP) in the pathophysiology of migraine has led to the development of multiple therapies targeting the CGRP pathway.^1,2 Several agents have been approved based on favourable efficacy and safety data from clinical trials.¹ However, the extensive physiological roles of CGRP suggest that blocking this key peptide may have pote