Difficult-to-treat migraine is associated with a substantial economic burden

Migraine can be considered difficult-to-treat in patients who have an inadequate response to preventative therapies, psychiatric comorbidities or medication overuse.³ Migraine is most prevalent among adults during their most formative and productive years.^1,2 Migraine attacks can impair an individuals’ ability to function, which in turn interferes with the conduct of daily activities including occupational responsibilities; resulting in a loss of work productivity.^2,4 Psychiatric comorbidities are common amongst people with migraine, and can be associated with higher healthcare utilisation tendencies and medical costs.^5,6 In addition, medication overuse and inadequate response to preventative therapies are also associated with significant resource utilisation and economic burden.^4,7

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