Does the blood–brain barrier open during a migraine attack?
Another intriguing session at CONy 2019 featured a debate on whether the blood–brain barrier (BBB) transiently opens during migraine attacks. Although inflammation and BBB disruption are important contributors to many neurologic disorders, and inflammation has been linked to migraine pathogenesis, it is still unclear whether BBB integrity is disrupted during migraine attacks.
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References
Hougaard A, Amin FM, Christensen CE, et al. Increased brainstem perfusion, but no blood-brain barrier disruption, during attacks of migraine with aura. Brain. 2017;140(6):1633-42.